Abstract: The present invention relates to a novel and improved process for the preparation of linagliptin, chemically known as (R)-8-(3-amino-piperidin-l-yl)-7-but-2-ynyl-3-methyl-l-(4-methyl-quinazolin-2-ylmethyl)-3, 7-dihydro-purine-2, 6-dione through novel intermediates using (3S)-l-(7-(but-2-ynyl)-3-methyl-l-((4-methylquinazolin-2-yl)methyl)-2, 6-dioxo-2, 3, 6, 7-tetrahydro-lH-purin-8-yl) piperidin-3-yl methanesulfonate (K) and (3R)-8-(3-azidopiperidin-l-yl)-7-(but-2-ynyl)-3-methyl-l-((4-methylquinazolin-2-yl)methyl)-1 H-purine-2,6-(3H,7H)-dione (L).
Year | CBR Date | CBR Number | Renwal Amount | Renwal Date | Normal Due Date | Renwal To | Renwal From | Due Date with Extension | Reneal Certificate Number |
---|---|---|---|---|---|---|---|---|---|
3rd year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2016 | 17/05/2015 | 20/03/2019 | 23750 |
4th year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2017 | 17/05/2016 | 20/03/2019 | 23750 |
5th year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2018 | 17/05/2017 | 20/03/2019 | 23750 |
6th year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2019 | 17/05/2018 | 20/03/2019 | 23750 |
7th year | 03/07/2018 | 18336 | 13200 | 03/07/2018 | 17/05/2019 | 17/05/2020 | 17/05/2019 | 17/11/2019 | 23750 |
8th year | 13/03/2020 | 9129 | 13200 | 13/03/2020 | 17/05/2020 | 17/05/2021 | 17/05/2020 | 17/11/2020 | 16172 |
9th year | 18/03/2021 | 9855 | 13200 | 18/03/2021 | 17/05/2021 | 17/05/2022 | 17/05/2021 | 17/11/2021 | 16903 |
10th year | 09/03/2022 | 9290 | 13200 | 09/03/2022 | 17/05/2022 | 17/05/2023 | 17/05/2022 | 17/11/2022 | 16221 |
11th year | 06/03/2023 | 10157 | 26400 | 06/03/2023 | 17/05/2023 | 17/05/2024 | 17/05/2023 | 17/11/2023 | 17951 |
12th year | 04/03/2024 | 14553 | 26400 | 04/03/2024 | 17/05/2024 | 17/05/2025 | 17/05/2024 | 17/11/2024 | 43520 |
13th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
14th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
15th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
16th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
17th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
18th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
19th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
20th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
Name | Date | |
---|---|---|
1 | 297872-Correspondence_Renewal Fee_06-03-2023.pdf | 2023-03-06 |
2 | 297872-Correspondence_Renewal Fee_09-03-2022.pdf | 2022-03-09 |
3 | 297872-Correspondence_Renewal Fee_18-03-2021.pdf | 2021-03-18 |
4 | 2189-CHE-2013_Correspondence_Renewal_23-03-2020.pdf | 2020-03-23 |
5 | 2189-CHE-2013-Renewal Fee_13-03-2020.pdf | 2020-03-13 |
6 | Form27_Working of the Patented Invention_01-04-2019.pdf | 2019-04-01 |
7 | Correspondence by Agent_Renewal Fee_03-07-2018.pdf | 2018-07-03 |
8 | 2189-CHE-2013-IntimationOfGrant20-06-2018.pdf | 2018-06-20 |
9 | 2189-CHE-2013-PatentCertificate20-06-2018.pdf | 2018-06-20 |
10 | Abstract_Granted 297872_20-06-2018.pdf | 2018-06-20 |
11 | Claims_Granted 297872_20-06-2018.pdf | 2018-06-20 |
12 | Description_Granted 297872_20-06-2018.pdf | 2018-06-20 |
13 | Amended Pages Of Specification_FER Reply_27-02-2018.pdf | 2018-02-27 |
14 | Claims_FER Reply_27-02-2018.pdf | 2018-02-27 |
15 | Correspondence by Applicant_Reply to Examination Report_27-02-2018.pdf | 2018-02-27 |
16 | Form2 Title Page_FER Reply_27-02-2018.pdf | 2018-02-27 |
17 | Form3_FER Reply_27-02-2018.pdf | 2018-02-27 |
18 | 2189-CHE-2013-COMPLETE SPECIFICATION [21-02-2018(online)].pdf | 2018-02-21 |
19 | 2189-CHE-2013-FER_SER_REPLY [21-02-2018(online)].pdf | 2018-02-21 |
20 | 2189-CHE-2013-OTHERS [21-02-2018(online)].pdf | 2018-02-21 |
21 | 2189-CHE-2013-FER.pdf | 2017-10-19 |
22 | 2189-CHE-2013 CORRESPONDENCE OTHERS 25-06-2013.pdf | 2013-06-25 |
23 | 2189-CHE-2013 CORRESPONDENCE OTHERS 25-06-2013.pdf | 2013-06-25 |
24 | 2189-CHE-2013 FORM-18 25-06-2013.pdf | 2013-06-25 |
25 | 2189-CHE-2013 FORM-5 25-06-2013.pdf | 2013-06-25 |
26 | 2189-CHE-2013 CORRESPONDENCE OTHERS 25-06-2013.pdf | 2013-06-25 |
27 | 2189-CHE-2013 FORM-9 25-06-2013.pdf | 2013-06-25 |
28 | 2189-CHE-2013 ABSTRACT 17-05-2013.pdf | 2013-05-17 |
29 | 2189-CHE-2013 CLAIMS 17-05-2013.pdf | 2013-05-17 |
30 | 2189-CHE-2013 CORRESPONDENCE OTHERS 17-05-2013.pdf | 2013-05-17 |
31 | 2189-CHE-2013 DESCRIPTION (COMPLETE) 17-05-2013.pdf | 2013-05-17 |
32 | 2189-CHE-2013 FORM-1 17-05-2013.pdf | 2013-05-17 |
33 | 2189-CHE-2013 FORM-2 17-05-2013.pdf | 2013-05-17 |