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Patent Information
Application Number
2189/CHE/2013
Patent Number
297872
Invention Field
CHEMICAL
Publication Type
INA
Publication Number
29/2013
Status
Grant Date
Filing Date
Grant Date
2018-06-20
Renewal Date
2025-05-17
Abstract
Abstract: The present invention relates to a novel and improved process for the preparation of linagliptin, chemically known as (R)-8-(3-amino-piperidin-l-yl)-7-but-2-ynyl-3-methyl-l-(4-methyl-quinazolin-2-ylmethyl)-3, 7-dihydro-purine-2, 6-dione through novel intermediates using (3S)-l-(7-(but-2-ynyl)-3-methyl-l-((4-methylquinazolin-2-yl)methyl)-2, 6-dioxo-2, 3, 6, 7-tetrahydro-lH-purin-8-yl) piperidin-3-yl methanesulfonate (K) and (3R)-8-(3-azidopiperidin-l-yl)-7-(but-2-ynyl)-3-methyl-l-((4-methylquinazolin-2-yl)methyl)-1 H-purine-2,6-(3H,7H)-dione (L).
Applicants
1. DIVI'S LABORATORIES LTD.
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
Inventors
1. MURALI KRISHNA PRASAD DIVI
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
2. NAGESWARA RAO BOLNENI
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
3. NAGA VENKATA SASTRY MUDIGANTI
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
Specification
1. MURALI KRISHNA PRASAD DIVI
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
2. NAGESWARA RAO BOLNENI
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
3. NAGA VENKATA SASTRY MUDIGANTI
7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016
Eregister
| Year | CBR Date | CBR Number | Renwal Amount | Renwal Date | Normal Due Date | Renwal To | Renwal From | Due Date with Extension | Reneal Certificate Number |
|---|---|---|---|---|---|---|---|---|---|
| 3rd year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2016 | 17/05/2015 | 20/03/2019 | 23750 |
| 4th year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2017 | 17/05/2016 | 20/03/2019 | 23750 |
| 5th year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2018 | 17/05/2017 | 20/03/2019 | 23750 |
| 6th year | 03/07/2018 | 18336 | 4400 | 03/07/2018 | 20/09/2018 | 17/05/2019 | 17/05/2018 | 20/03/2019 | 23750 |
| 7th year | 03/07/2018 | 18336 | 13200 | 03/07/2018 | 17/05/2019 | 17/05/2020 | 17/05/2019 | 17/11/2019 | 23750 |
| 8th year | 13/03/2020 | 9129 | 13200 | 13/03/2020 | 17/05/2020 | 17/05/2021 | 17/05/2020 | 17/11/2020 | 16172 |
| 9th year | 18/03/2021 | 9855 | 13200 | 18/03/2021 | 17/05/2021 | 17/05/2022 | 17/05/2021 | 17/11/2021 | 16903 |
| 10th year | 09/03/2022 | 9290 | 13200 | 09/03/2022 | 17/05/2022 | 17/05/2023 | 17/05/2022 | 17/11/2022 | 16221 |
| 11th year | 06/03/2023 | 10157 | 26400 | 06/03/2023 | 17/05/2023 | 17/05/2024 | 17/05/2023 | 17/11/2023 | 17951 |
| 12th year | 04/03/2024 | 14553 | 26400 | 04/03/2024 | 17/05/2024 | 17/05/2025 | 17/05/2024 | 17/11/2024 | 43520 |
| 13th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 14th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 15th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 16th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 17th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 18th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 19th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 20th year | -- | -- | -- | -- | -- | -- | -- | -- | -- |
Specification
Documents
Documents
| Name | Date | |
|---|---|---|
| 29 | 2189-CHE-2013 CLAIMS 17-05-2013.pdf | 2013-05-17 |
| 30 | 2189-CHE-2013 CORRESPONDENCE OTHERS 17-05-2013.pdf | 2013-05-17 |
| 31 | 2189-CHE-2013 DESCRIPTION (COMPLETE) 17-05-2013.pdf | 2013-05-17 |
| 32 | 2189-CHE-2013 FORM-1 17-05-2013.pdf | 2013-05-17 |
| 33 | 2189-CHE-2013 FORM-2 17-05-2013.pdf | 2013-05-17 |