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Process For The Preparation Of Linagliptin Via Novel Intermediates
Updated over 1 year ago
Abstract
The present invention relates to a novel and improved process for the preparation of linagliptin, chemically known as (R)-8-(3-amino-piperidin-l-yl)-7-but-2-ynyl-3-methyl-l-(4-methyl-quinazolin-2-ylmethyl)-3, 7-dihydro-purine-2, 6-dione through novel intermediates using (3S)-l-(7-(but-2-ynyl)-3-methyl-l-((4-methylquinazolin-2-yl)methyl)-2, 6-dioxo-2, 3, 6, 7-tetrahydro-lH-purin-8-yl) piperidin-3-yl methanesulfonate (K) and (3R)-8-(3-azidopiperidin-l-yl)-7-(but-2-ynyl)-3-methyl-l-((4-methylquinazolin-2-yl)methyl)-1 H-purine-2,6-(3H,7H)-dione (L).
Information
| Application ID | 2189/CHE/2013 |
| Invention Field | CHEMICAL |
| Date of Application | 2013-05-17 |
| Publication Date | 2013-07-19 |
| Status | granted |
| Publication Type | 1 |
| Date of Certificate | |
| Patent Number | |
| Grant Date | |
| Renewal Date | |
| Publication Number | 29/2013 |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| DIVI'S LABORATORIES LTD. | 7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016 | India | India |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| MURALI KRISHNA PRASAD DIVI | 7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016 | India | India |
| NAGESWARA RAO BOLNENI | 7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016 | India | India |
| NAGA VENKATA SASTRY MUDIGANTI | 7-1-77/E/1/303, DHARAM KARAN ROAD, AMEERPET, HYDERABAD - 500 016 | India | India |