Bridged Bicyclic Compounds As Farnesoid X Receptor Modulators


Updated over 1 year ago

Abstract

The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Information

Application ID 202017022199
Invention Field CHEMICAL
Date of Application 2020-05-27
Email archana@anandandanand.com
Publication Date 2020-08-21
Status published
Publication Type
Date of Certificate
Patent Number
Grant Date
Renewal Date
Publication Number 34/2020

Applicants

Name Address Country Nationality
BRISTOL-MYERS SQUIBB COMPANY Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.

Inventors

Name Address Country Nationality
YOON, David S. c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.
ANUMULA, Rushith Kumar c/o Syngene International Limited, Biocon Special Economic Zone Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area IV Phase Jigani Link Road, Bommasandra, Bangalore 560 099 Karnataka India India
CHERUKU, Srinivas c/o Syngene International Limited, Biocon Special Economic Zone Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area IV Phase Jigani Link Road, Bommasandra, Bangalore 560 099 Karnataka India India
HUANG, Yanting c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.
JURICA, Elizabeth Anne c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.
MENG, Wei c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.
NARA, Susheel Jethanand c/o Syngene International Limited, Biocon Special Economic Zone Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area IV Phase Jigani Link Road, Bommasandra, Bangalore 560 099 Karnataka India India
NARAYAN, Rishikesh c/o Goa Engineering College (GEC) Campus Farmagudi Ponda 403401 Goa India India
SISTLA, Ramesh Kumar c/o Syngene International Limited, Biocon Special Economic Zone Biocon Park, Plot No. 2 & 3, Bommasandra Industrial Area IV Phase Jigani Link Road, Bommasandra, Bangalore 560 099 Karnataka India India
WU, Ximao c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.
ZHAO, Guohua c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton, New Jersey 08543 U.S.A. U.S.A.

Specification