Patent Information

Application Number
1845/CHE/2005
Patent Number
253739
Invention Field
CHEMICAL
Publication Type
INA
Publication Number
35/2007
Status
Grant Date
Filing Date
Grant Date
2012-08-22
Renewal Date
2023-12-18

Abstract

Abstract: The present invention relates to a process for the preparation of substantially pure 1-(aminomethyl)-l-cyclohexane acetic acid hydrochloride of formula (II) viz. gabapentin hydrochloride through gabalactam (I) which in turn arises from 3,3-pentamethylene glutarimide of formula (IV). The imide, 3,3-pentamethylene glutarimide of formula (IV) is obtained in a reaction between the diacid and urea under special conditions. The imide thus obtained, without isolation, is subjected to reaction with sodium hypobromite orsodium hypochlorite to yield 2-azaspiro [4,5] decan-3-one (gabalactam) of formula (I), which is transformed to gabapentin hydrochloride (II) by heating with concentrated hydrochloric acid under rigorously worked out conditions. Alternatively, the gabalactam (I) on treatment with dry hydrogen chloride gas in an alcohol preferably isopropyl alcohol yields gabalactam hydrochloride, which is transformed to gabapentin hydrochloride (II) by heating with water. Gabapentin hydrochloride (II) can then be easily converted to gabapentin in a known manner.

Applicants

1. HIKAL LIMITED
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076

Inventors

1. DR ASHOK PATEL
HIKAL LTD PANOLI PLANT PLOT NO 629/630 GIDC INDL.AREA PANOLI
2. SUSHIL KUMAR TIWARI
HIKAL LTD PANOLI PLANT PLOT NO 629/630 GIDC INDL.AREA PANOLI
3. MARIADAS ARUL SELVAN
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
4. SUVARNA KRISHNANAND SHENVI
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
5. PATHALINGAPPA HARESH KUMAR
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
6. DR RAJENDRA PERSHAD GUPTA
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
7. DR KUPPUSWAMY NAGARAJAN
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
8. DR LYER VENKATACHALAM SANKAR
36/301 EMAMI NEST 16TH CROSS 8TH MAIN MALLESWARAM BANGALORE 560 003

Specification

1. DR ASHOK PATEL
HIKAL LTD PANOLI PLANT PLOT NO 629/630 GIDC INDL.AREA PANOLI
2. SUSHIL KUMAR TIWARI
HIKAL LTD PANOLI PLANT PLOT NO 629/630 GIDC INDL.AREA PANOLI
3. MARIADAS ARUL SELVAN
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
4. SUVARNA KRISHNANAND SHENVI
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
5. PATHALINGAPPA HARESH KUMAR
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
6. DR RAJENDRA PERSHAD GUPTA
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
7. DR KUPPUSWAMY NAGARAJAN
32/1 KALENA AGRAHARA BANNERAGHATTA ROAD BANGALORE 560 076
8. DR LYER VENKATACHALAM SANKAR
36/301 EMAMI NEST 16TH CROSS 8TH MAIN MALLESWARAM BANGALORE 560 003

Eregister



Year CBR Date CBR Number Renwal Amount Renwal Date Normal Due Date Renwal To Renwal From Due Date with Extension Reneal Certificate Number
3rd year 29/08/2012 9822 2000 29/08/2012 22/11/2012 16/12/2008 16/12/2007 22/05/2013 8583
4th year 29/08/2012 9822 2000 29/08/2012 22/11/2012 16/12/2009 16/12/2008 22/05/2013 8583
5th year 29/08/2012 9822 2000 29/08/2012 22/11/2012 16/12/2010 16/12/2009 22/05/2013 8583
6th year 29/08/2012 9822 2000 29/08/2012 22/11/2012 16/12/2011 16/12/2010 22/05/2013 8583
7th year 29/08/2012 9822 6000 29/08/2012 22/11/2012 16/12/2012 16/12/2011 22/05/2013 8583
8th year 06/11/2012 15032 6000 06/11/2012 16/12/2012 16/12/2013 16/12/2012 16/06/2013 10854
9th year 13/12/2013 17676 6000 13/12/2013 16/12/2013 16/12/2014 16/12/2013 16/06/2014 12256
10th year 16/12/2014 23498 12000 16/12/2014 16/12/2014 16/12/2015 16/12/2014 16/06/2015 18668
11th year 14/12/2015 25453 24000 14/12/2015 16/12/2015 16/12/2016 16/12/2015 16/06/2016 21355
12th year 15/12/2016 34615 24000 15/12/2016 16/12/2016 16/12/2017 16/12/2016 16/06/2017 23722
13th year 01/12/2017 37179 24000 01/12/2017 16/12/2017 16/12/2018 16/12/2017 16/06/2018 35570
14th year 07/12/2018 35293 24000 07/12/2018 16/12/2018 16/12/2019 16/12/2018 16/06/2019 41938
15th year 10/12/2019 40748 24000 10/12/2019 16/12/2019 16/12/2020 16/12/2019 16/06/2020 57773
16th year 09/12/2020 41635 40000 09/12/2020 16/12/2020 16/12/2021 16/12/2020 16/06/2021 71538
17th year 12/11/2021 42338 40000 12/11/2021 16/12/2021 16/12/2022 16/12/2021 16/06/2022 73293
18th year 09/12/2022 49979 40000 09/12/2022 16/12/2022 16/12/2023 16/12/2022 16/06/2023 81848
19th year -- -- -- -- -- -- -- -- --
20th year -- -- -- -- -- -- -- -- --

Specification

Documents

Documents
Name Date
1 1845-CHE-2005-FORM-27 [30-09-2024(online)].pdf 2024-09-30
2 1845-CHE-2005-RELEVANT DOCUMENTS [29-09-2023(online)].pdf 2023-09-29
3 1845-CHE-2005-RELEVANT DOCUMENTS [26-09-2022(online)].pdf 2022-09-26
4 1845-CHE-2005-RELEVANT DOCUMENTS [30-09-2021(online)].pdf 2021-09-30
5 1845-CHE-2005-RELEVANT DOCUMENTS [29-03-2020(online)].pdf 2020-03-29
6 1845-CHE-2005-RELEVANT DOCUMENTS [16-03-2019(online)].pdf 2019-03-16
7 1845-CHE-2005-RELEVANT DOCUMENTS [30-03-2018(online)].pdf 2018-03-30
8 Form 27 [04-03-2017(online)].pdf 2017-03-04
9 1845-CHE-2005_EXAMREPORT.pdf 2016-07-02
10 1845-CHE-2005 AMENDED CLAIMS 30-05-2012.pdf 2012-05-30
11 1845-CHE-2005 CORRESPONDENCE OTHERS 30-05-2012.pdf 2012-05-30
12 1845-CHE-2005 AMENDED CLAIMS 25-10-2011.pdf 2011-10-25
13 1845-CHE-2005 AMENDED PAGES OF SPECIFICATION 25-10-2011.pdf 2011-10-25
14 1845-CHE-2005 CORRESPONDENC E OTHERS 25-10-2011.pdf 2011-10-25
15 1845-che-2005-abstract.pdf 2011-09-03
16 1845-che-2005-claims.pdf 2011-09-03
17 1845-che-2005-correspondnece-others.pdf 2011-09-03
18 1845-che-2005-description(complete).pdf 2011-09-03
19 1845-che-2005-description(provisional).pdf 2011-09-03
20 1845-che-2005-form 1.pdf 2011-09-03
21 1845-che-2005-form 26.pdf 2011-09-03
22 1845-che-2005-form 3.pdf 2011-09-03
23 1845-che-2005-form 5.pdf 2011-09-03
24 1845-CHE-2005 FORM-13 08-10-2010.pdf 2010-10-08