Abstract
Abstract:
The present invention discloses a novel process for the preparation of (2S, 3S, 5S)-5-amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-l,6-diphenylhexane hydrochloride of formula II, which is a key intermediate in the preparation of cobicistat, a drug under experimental investigation for use in the treatment of infection with the human immunodeficiency virus (HIV).
Inventors
Country: India
1. MANJATHURU, MAHALINGA
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
2. MAYEKAR, ANIL NARAYAN
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
3. DERAMBALA, YOGEESH
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
4. CHANDRAPPA, PRASHANTHA NERLIKERE
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
5. VASUDEVA, PEJAKALA KAKRANNAYA
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
6. ARULMOLI, THANGAVEL
C/O SEQUENT SCIENTIFIC LIMITED
STAR - II, OPP. TO INDIAN INSTITUTE OF MANAGEMENT, BANNERGHATTA ROAD, BANGALORE - 560 076 KARNATAKA, INDIA
Country: India
7. DAS, GAUTAM KUMAR
C/O SEQUENT SCIENTIFIC LIMITED
STAR - II, OPP. TO INDIAN INSTITUTE OF MANAGEMENT, BANNERGHATTA ROAD, BANGALORE - 560 076 KARNATAKA, INDIA
Specification
Country: India
1. MANJATHURU, MAHALINGA
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
2. MAYEKAR, ANIL NARAYAN
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
3. DERAMBALA, YOGEESH
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
4. CHANDRAPPA, PRASHANTHA NERLIKERE
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
5. VASUDEVA, PEJAKALA KAKRANNAYA
C/O SEQUENT SCIENTIFIC LIMITED
120 A & B, INDUSTRIAL AREA, BAIKAMPADY,
MANGALORE-575011, KARNATAKA, INDIA
Country: India
6. ARULMOLI, THANGAVEL
C/O SEQUENT SCIENTIFIC LIMITED
STAR - II, OPP. TO INDIAN INSTITUTE OF MANAGEMENT, BANNERGHATTA ROAD, BANGALORE - 560 076 KARNATAKA, INDIA
Country: India
7. DAS, GAUTAM KUMAR
C/O SEQUENT SCIENTIFIC LIMITED
STAR - II, OPP. TO INDIAN INSTITUTE OF MANAGEMENT, BANNERGHATTA ROAD, BANGALORE - 560 076 KARNATAKA, INDIA