Abstract:
ABSTRACT
A PROCESS FOR PREPARATION OF 4-METHYLENEPIPERIDINE HYDROCHLORIDE
The present disclosure relates to a process for preparing 4-methylene piperidine hydrochloride. The process comprises alkylating 1-benzylpiperidine-4-one using an alkylating agent in the presence of an alkali and a first fluid medium to obtain 1-benzyl-4-methylidenepiperidine. In the next step, 1-benzyl-4-ethylidenepiperidine is subjected to debenzylation using ethyl chloroformate in the presence of a second fluid medium to obtain N-carbethoxy-4-methylene piperidine. N-carbethoxy-4-methylene piperidine is deprotected using a base in the presence of a third fluid medium to obtain 4-methylidenepiperidine. 4-methylidenepiperidine is then treated with anhydrous hydrochloride gas in the presence of a fourth fluid medium to obtain 4-methylene piperidine hydrochloride having purity greater than 95%.
